Upstream Processing
Automated Upstream Processing
Comprehensive automation solutions for cell cultivation in cell and gene therapy
From inoculum preparation to cell expansion – sterile, reproducible, and fully documented upstream processes with gentle handling.
Applications
Upstream solutions for cell and gene therapy manufacturing
Standardization of Early Phases for Maximum Yield
In the manufacturing of cell and gene therapies, standardization of early phases is critical for the yield and quality of the final product. Our solutions automate critical process steps to eliminate human variability and minimize contamination risks in the sterile zone, with gentle handling to reduce cell stress.
- Complete Integration of Customer Process: We transfer your individual manual laboratory protocols into an automated workflow to enable seamless scaling from laboratory to production scale.
- Automated Sample Preparation: Our robotic solution "Sally" performs precise handling of vials and tubes for initial cell seeding with gentle handling.
- Equipment Integration: Complete automation of the workflow through integration of centrifuges, heating devices, and stirrers directly into the workspace.
- Intelligent Liquid Handling: Precise addition of media and reagents as well as automated sampling under sterile conditions.
- Inline Sensors: Continuous monitoring of critical parameters such as temperature and cell growth for optimal control of the scale-up process.
- Highest Data Integrity: Complete digital recording of all process parameters for GMP-compliant batch records.
Automation of Repetitive Tasks for Consistent Process Quality
In cell therapy production, manual handling of large-volume vessels poses a significant risk to reproducibility and employee safety. Our specialized robotic solutions automate these repetitive tasks to ensure consistent process quality with maximum flexibility and gentle handling to minimize cell stress.
- Large-Scale Cultivation: Specialized robotic systems for ergonomic and safe handling of CellStacks and cell culture bottles.
- Maximum Flexibility: Robotics enable rapid switching between different vessel types while maintaining high process reliability.
- Gentle Movement: Optimized acceleration profiles when moving and tilting culture bottles to avoid cell stress and medium spillage.
- Process Integration: Complete integration of incubators and additional process equipment for seamless, automated transfer of your cell cultures.
- Scalable Productivity: Automation of repetitive tasks to increase throughput while relieving laboratory staff.
- Precise Positioning: Repeatable placement of stacks in connected systems for a complete and documented process chain.
Let's automate your upstream processes.
I personally advise you on customized cell culture automation solutions for your specific requirements.
